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4 edition of Accumulation of serum lipoprotein in the livers of rats fed orotic acid found in the catalog.

Accumulation of serum lipoprotein in the livers of rats fed orotic acid

Lawrence Avery Pottenger

Accumulation of serum lipoprotein in the livers of rats fed orotic acid

by Lawrence Avery Pottenger

  • 210 Want to read
  • 37 Currently reading

Published .
Written in English


Edition Notes

Statementby Lawrence Avery Pottenger.
Classifications
LC ClassificationsMicrofilm 40715 (R)
The Physical Object
FormatMicroform
Paginationviii, 112 leaves
Number of Pages112
ID Numbers
Open LibraryOL1827088M
LC Control Number89894167

Serum lipoproteins accumulation in the livers of orotic acid-fed rats. J Lipid Res. ; – View in Article | PubMed | Google Scholar; Pottenger, LA, Frazier, LE, Dubien, LH, Getz, GS, and Wissler, RW. Carbohydrate composition of lipoprotein apoproteins isolated from rat plasma and from the livers of rats fed orotic by: Changes In Serum Lipid Profiles And Heart Rate In Rats Treated With Aqueous Garlic Extract 4 of 6 atherosclerosis and increased risk of coronary heart disease. Clinical studies in human have shown that lowering levels of serum cholesterol (especially LDL-c) with diet or drugs decreases the incidence of coronary heart disease (Gotto et al, ).

  The following procedure is adapted from Havel’s method of adjusting the density of the serum (with a salt) and ultracentrifugation to float up the lipoproteins [1]. After removal of the lipoproteins, excess salt is removed by dialysis. Procedural considerations 1. Lipoprotein flotation rate (based on hydrated density). Male, 5-week-old Wistar rats were divided into 2 dietary groups of 7 rats each, one group receiving a control AING diet and the other receiving a 5% OEBP-containing diet. After the rats had been fed on their respective diets for 31 days, their serum and liver lipids contents and fecal cholesterol, bile acid, and nitrogen excretion were measured.

Fatty substances called triglycerides and cholesterol cannot be dissolved in the blood and depend on a transport system that takes them from the organs that produce them (the gut and liver) to cells. The two most important lipoproteins in this transport system are called low-density lipoprotein (LDL) and high-density lipoprotein (HDL). Dietary Models for Inducing Hypercholesterolemia in Rats Sheyla Leite Matos1, Heberth de Paula1, Maria Lúcia Pedrosa2, Rinaldo Cardoso dos Santos1, Eduardo Luiz de Oliveira2, Deoclécio Alves Chianca Júnior2 and Marcelo Eustáquio Silva1* 1 D ep a r tm no d e A l i os ; Ec a d N uçã U v da dF l O o P 0 MG - Brazil.


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Accumulation of serum lipoprotein in the livers of rats fed orotic acid by Lawrence Avery Pottenger Download PDF EPUB FB2

Rats fed on a diet containing 1% orotic acid for 7 days develop a fatty liver and there is inhibition of the secretion of low-density lipoproteins without change in general liver protein synthesis. An attempt to characterize the nature of the lesion is by: Vol. 54, No. 2, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS CARBOHYDRATE COMPOSITION OF LIPOPROTEIN APOPROTEINS ISOLATED FROM RAT PLASMA AND FROM THE LIVERS OF RATS FED OROTIC ACID L.

Pottenger, L. Frazier, L. DuBien, G. Getz and R. Wissler Departments of Pathology and Biochemistry University of Cited by: plasma @lipoprotein concentration fell within 7 days to less than 1% of normal.

It rebounded to normal within 48 hours following withdrawal of erotic acid or supplementation of the diet with % of adenine.

When perfused in situ, livers from erotic acid-fed rats released cr-lipoprotein, albumin, and. The concentrations of serum lipids and lipoproteins of rats fed 5% Lys and having vatty livers were also compared with those of rats fed the identical diet but lacking fatty livers when killed.

The total liver lipids, triglycerides and cholesterol of rats fed 15% casein +5% Lys wereand 2 Cited by: The effects of dietary shochu kasu (5%) on orotic acid-induced fatty liver were studied in rats. Liver triglyceride content of orotic acid-fed rats increased by 5-fold in comparison to basal group.

Serum lipids, lipoprotein composition and liver cholesterol in genetically obese Zucker rats fed semipurified diets containing either casein or soy protein. Terpstra AH, van Tintelen G, West CE. The effect of semipurified diets containing either casein or soy protein on serum lipids, lipoprotein composition and liver cholesterol was studied in Cited by: 6.

Fatty acid metabolism and lipid secretion by perfused livers from rats fed laboratory stock and sucrose-rich diets. Yamamoto M(1), Yamamoto I, Tanaka Y, Ontko JA. Author information: (1)Cardiovascular Research Program, Oklahoma Medical Research Foundation, Oklahoma by:   The source of free fatty acids (FFA) and the pathways contributing to the accumulation of neutral fats in livers of rats fed a cholesterol-enriched diet were investigated in this report.

Supplementation with 1% cholesterol in the diet for four weeks resulted in hepatomegaly in the rats. The contents of cholesterol and triacylglycerols (TG) per gram liver measured in rats fasted overnight Cited by: 85 INFLUENCE OF 20, 2$-DIAZA-CHOLESTEROL ON SERUM LIPOPROTEIN LIPIDS OF MATURE RATS 1.

Lester Smith and Jacqueline Dupont Biochemistry Department Howard university College of Medicine Washington, D. Novem ABSTRACT Five-month-old male rats were fed diets with or with2$-diaza- cholesterol (azasterol) for 6 by: 3.

Lipoprotein Lipase Expression, Serum Triacylglycerol and Tissue Lipid Deposition in Rats Fed on Switching Type of Diet and Treated with Glycyrrhizic Acid Hui Ping Yaw1*, So Ha Ton1, Shing Wei Ng1 and Khalid Abdul Kadir2 1School of Science, Monash University Sunway Campus, Jalan Lagoon Selatan, Bandar Sunway, Selangor Darul Ehsan, Malaysia.

Fatty liver is caused when rats are given orotic acid of the pyrimidine base in large quantities. The lack of B-group vitamins suppresses the biosynthesis of fatty acids.

A Comparison of Lipoprotein Secretion, Bile Production and Hepatic Morphology in Isolated Rat Livers Perfused with a Perfluorocarbon Emulsion or Rat Erythrocytes T~DE E. FELKER,' DONALD GANTZ,~ ANNA M. TERCYAK,' CHERYL OLIVA,' SUSANNE BENNETT CLARK'.^* AND Departments of 'Biophysics, 2Biochemistry and "Medicine and 4Physiology, Boston University School of Medicine, Cited by: 9.

The serum from fed animals had a higher VLDL triacylglycerol concentration than serum from animals fed each of the other diets. The concentration of apolipoprotein B was also high in the VLDL fraction from fed animals. The fatty acid composition of each lipoprotein fraction was affected by the nature of the lipid in the diet; the greatest Cited by:   It has been well established from epidemiological studies using a large number of subjects that low-density lipoprotein associated cholesterol (LDL-C) levels in serum correlates with atherosclerosis [].However, it is also well known that individual variations exist in response to hypercholesterolemia in animals or humans [2–4].Some individuals with high serum cholesterol and LDL-C do not Cited by: 3.

The effect of diet enriched with a monounsaturated fatty acid (olive oil) on serum lipoproteins, biliary cholesterol saturation index, and gallbladder motility compared with a standard low-fat diet was evaluated in 11 young volunteers admitted to a metabolic by: groups, the control and honey-fed (test) groups, ten in each group.

The rats weighed between gm at the start of the study. The control group was fed on normal rat (Pfizer-Nigeria) while the test group was fed on normal rat feed and honey (1ml of honey was added to 10ml of drinking water given once every day) for 22 weeks.

" Lipid alterations in the liver and serum of rats in histidine-excess and copper deficiency "Cited by: 9. tem. Addition of erotic acid ( mM) to the medium of cells obtained from sucrose-fed rats inhibited VLDL secretion by 50%, an effect prevented by the simulta- neous addition of adenine ( mM).

These results dem- onstrate for the first time that erotic acid can act di. Among rats fed the B 6 (−)BCAA(+) diet, about a half showed lipid deposition in the liver.

On the other hand, serum triacylglycerol levels in the B 6 (−)BCAA(+) group tended to be decreased. Hepatic triacylglycerol and cholesterol levels tended to increase in the B 6 (−)BCAA(+) group compared with the other three by: 6.

livers of these monkeyswereperfused byrecirculation with a lipoprotein-free medium for 4 h. The rate of accumulation of perfusate cholesterol was linear and greater in liver perfusatesfromtest diet-fed vs.

control diet-fed monkeys and was positively correlated with both the plasma cholesterol concentration and LDL size in the donor animal.

Start studying Chapter 6 Lipids. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Search. one end of the chain forms a carboxylic acid, and one end forms a methyl group. type of lipoprotein formed in enterocytes to transport lipids away from the GI tract.serum lipid: Any major lipid in the circulation–total cholesterol, HDL, LDL, TGs.

See Cholesterol, Triglyceride.-Bile Acid Resins bind and trap Bile Acid/Salts in the intestines and lead to excretion of Bile Acids/Salts into feces-Less Bile Acids/Salts taken up into Liver so Liver must synthesize more BIle Acids using Cholesterol-This stimulates LDL-receptor synthesis (which reduces serum LDL levels).